I really don't see why it's any of the Premier League's business whether there are replays in rounds 1 + 2, that surely have ben subject to EFL and National League consultation rather than by decree. I also xan't see how having replays in R3 is a problem for the Prem. They happen mid January, before Euro fixtures restart and rarely cause disruption (unless it clashes with SFL Cup semi finals (which could/should be sorted if the Prem and EFL could reach an agreement over funding).
I think R4 on you can make the argument about fixture clashes, and if L1 and L2 teams have got that far then they've probably done OK financially but then coming to a sensible agreement require people to listen to each other and to look for compromises, something football bodies have been singularly rubbish at.