Don't think I can recall what you would call a "lump in the throat" moment. Sheer joy of course when Bobby Stokes scored at Wembley, Armstrong scoring a last minute winner v Man Utd, MLT's last goal etc; etc;
On the negative side was sad when we got relegated in 1974 but always felt we'd be back, then of course relegation in 2005 though that was coming for quite a while, so many great Saints dying and so on.