Doctoroncall

Some good news from the work of Professor Gupta and team: 1. Omicron Spike protein mediates deficient cell entry and is inefficiently cleaved compared to Delta spike. We tested viral entry mediated by Wild Type, Delta and Omicron spikes using a pseudotyped virus system, infecting primary 3D lung alveolar organoids. 2. Omicron Spike protein induces relatively poor cell-cell fusion compared to WT and Delta. We expressed spike in cells stably expressing split GFP, so that Green signal could be measured over time upon cell-cell fusion and syncitia formation. The difference is significant. 3. What does this all mean? Efficient infection of lung cells could correlate with severity of lung disease. Syncitia or fused cells are often seen in respiratory tissues taken following severe disease. Delta was very good at both, in contrast to Omicron. Further work is needed. 4. We also tested how well antibodies from vaccinated individuals neutralised Omicron v Delta. We found that Omicron was poorly neutralised after two doses of mRNA or Ad vectored vaccine compared to Delta, but that the third dose (mRNA vaccine) rescued this at an early time point. 5. In summary this work suggests that Omicron does appear to have become more immune evasive, but that properties associated with disease progression *may* be attenuated to some extent. The significant growth of Omicron nevertheless represents a major public health challenge.

There was, https://tactical.vote. Obviously didn’t help.

39993 according to the daily telegraph

Their best defender is likely to be off in January. Only six months left on his contract they want to cash in. Just a question of how good is his replacement.

Cone technician customer service manager cashier (match day)

They have more money so ‘structures’ become less important. I would say the top six have filled five of those spaces for the last dozen seasons, the top four places for longer, the only blemish being the Leicester league win when Saints finished in sixth place. Newcastle can crash the party now, probably at spurs expense but teams have tried to spend to compete and have disappeared (Blackburn and Villa). Only having something different - manager, investment, academy, transfers, luck, or a combination of things will get a team the odd fifth or sixth place.

You will have one of those for the booster. Have a word with your GP about your experience and what to expect if you go for a booster.

But it seems the tories can afford to give these gifts and still be top of the polls.

And more selective.

More studies ongoing looking at possible effects from having severe Covid. Article in the Telegraph, link if you have access: How Covid may affect your heart

I don’t think the players are able to mentally focus on their shape and the press for two halves, especially when the opposition changes things at half time. Also It’s hard to maintain momentum and dictate terms if there is a player or two that has a lapse, makes a mistake or is out of place.

Serious coronavirus infections may significantly damage long-term health (as measured by death) compared to mild or moderate cases: Article Patient deaths may not be linked to COVID-19 directly as deaths could occur months after the infection.

Glad Tielemans and Pereira are out. Just need to have Hasenhüttl behave sensibly with the line up, formation and subs like he was pre Norwich and we have chance.

For those with more time on their hands and go beyond the generalities of ‘the science’ and other vagaries, this conference is starting today. The mRNA Applications in Discovery & Development, taking place November 30 - December 2, 2021. Delivered as a 3-day complimentary webcast series, industry leaders and service providers will showcase the power and diversity of mRNA technologies and applications across discovery, R&D, manufacturing, and delivery. It’s free… this session maybe of particular interest: Sequence in, mRNA out. A new paradigm to accelerate discovery of mRNA vaccines and therapeutics

How does science tell you this? Of course I’m not expecting a reply as that isn’t your thing. Carry on with all these generalisation, it’s entertaining.

Do you think that is typical of SARs-COV-2 or of viruses in general? Is the DDR pathway inhibited and therefore apoptosis induced?

One thing we have always done well at in this country is the surveillance of such pathogens and I'm not talking about Facebook variants.

All vaccines will be used for boosters but predominantly the mRNA ones as there is growing evidence mixing is best, but for those that cannot tolerate the mRNA based vaccines, AZ will be used. So after receiving the Pfizer jab, I get the Moderna booster!

There seems to be an expectation that all youngsters will develop into fantastic players as soon as they turn pro. Unfortunately it doesn’t work like that. As a club, Saints do give plenty of time to see if players fulfil their potential- perhaps sometimes the method isn’t right but certainly better than most clubs.

He is likely to appeal. His defence lawyers are currently looking into it.

Things are looking good, obviously still early days and it would be very interesting to get the story of his time in Italy. At least there were some positive views unlike the ~£18m wasted on the Carrillo where I didn’t see one!

Nothing like the Koeman situation as the board and manager are working towards an agreed goal. If Ralph feels he would be better off at Villa, that’s a different issue.

some of the names on that list make no sense.

I'm looking to go to Octopus as I have solar and batteries. I thought the electric prices were high from 17:00 to 19:00 and were much lower during the early hours than during the day. Is that not the case?

It's certainly not a positive start for him but early days as it was with the others, and lets not forget he is regarded as a fourth choice CB. I wouldn't say the general quality of the CBs has dramatically decreased because of one regular player leaving and a CB joining or are you saying the other players have regressed?