aintforever

It could all just be a big conspiracy or it could be that B.1.617 has several mutations that are present in other variants of interest/concern or that have been shown to have antigenic escape in laboratory experiments. Discussed here are changes in positions 484, 452 and 681. E484Q is present in B.1.617. Mutations in position 484 are present in the three global variants of concern, but these variants contains E484K. There is limited evidence for the role of E484Q in immune escape – it was shown to have reduced neutralisation by some but not all convalescent plasma samples from people who have had natural infection with SARS-CoV-2 using an experimental system (Greaney et al., 2021, Cell Host & Microbe 29, 463–476). L452R is present in B.1.617. This is present in several variants of interest, including B.1.429 (associated with California). This mutation has been associated with weaker neutralisation of the virus by convalescent plasma from people who have been infected with SARS-CoV-2, and/or some monoclonal antibodies in laboratory experiments. P681R is present in B.1.617. P681R or P681H is also present in several variants under investigation in the UK, including A.23.1/E484K, B.1.1.7 and B1.318. This is located adjacent to the furin cleavage site of the spike protein, which could mean a change in spike protein processing or other changes in biology. More evidence is needed to understand the virus changes that result from the specific combination of mutations present in B.1.617. What do you reckon?

So you will boo your own players for making a political gesture even though they have already made it crystal clear their gesture is not political in any way. Brilliant Maybe during the close season you can think up other imaginary stuff to get angry about?

Anyone with half a brain can see that it is just a generic anti-racism gesture, clearly you don’t qualify for that. Keep on pissing your pants over the terrible Marxist footballers who want to defund the plod if you want but you are just making stuff up to get angry about.

If you read the players statement they make it clear they are not supporting any political group - you are inventing stuff to get angry about.

Always room for improvement, if The Saints lads want to keep taking the knee before games good on them. I’m certainly not in a position to tell Redmond and Walcott that they should not try and make a difference.

Of course it is, football and society as a whole has moved on a lot in the last few decades.

It's almost as if they are looking for a reason to oppose it, who would have thought. I think we all know the types.

It’s obviously not impossible but it is much much harder than when I got on the ladder, to say otherwise is complete bollocks. When I brought my first house I barely had a penny to my name and my mortgage was 101%, I didn’t have to give up any luxuries whatsoever. Buying was actually easier than renting because I didn’t have to find a deposit in advance.

You think?

Brilliant, I knew the village idiot would turn up. You fed up with being made to look silly on the Coronavirus thread with your junior-school level understanding of virology?

Keep pissing your pants over a bunch of lads trying to stop racism if you want, it's sad and funny in equal measure.

So you applauded a bunch of cunts booing our own players because they made an anti-racism gesture. Bravo, what a fucking hero you are.

Booing a bunch of lads trying to combat racism - big man.

True, but not in any way ironic.

The Poppy isn't a political symbol but it has links to the British army in the same way.

No one is outraged, just not pissing our pants over a bunch of footballers making an anti-racism gesture.

Just like getting down on one knee then.

And who definitely say nothing when the Poppy is involved. Funny that.

Loads of players have stopped doing it - guess what, no one cares.

No one is asking to take part in it you bell-end.

You seriously think that would work? Wow

My whole point was that variants are a legitimate concern and not some made up scare story, and you prove my point by posting a quote about how the government are investing in 50 million new vaccines to combat future variants. You really should stay away from anything science related, maybe stick to threads about floor sweeping.

That is just complete bollocks, there have been loads of variants but only a few have been labelled as of concern. According to Sky News: In lab tests, the South African variant (B.1.351) and Brazil variant (P.1) both have a key mutation, E484K, which can help the virus evade antibodies produced by vaccines or by having had COVID-19. It is also more transmissible. that is why certain mutations are of concern and why they are testing the Indian variant now. You clearly struggle with anything science related, labelling something as concern and doing tests is not crying wolf.

Where is the quote of them saying the vaccines don’t work?

Have SAGE ever said the vaccines will not work? From what I have read they are waiting for more information - that’s exactly what studies like this are for.